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Proteintech
ATPIF1 Polyclonal Antibody
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Product Details
12067-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATPIF1 Fusion Protein Ag2704 (1-106 aa encoded by BC009677)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAVTALAAR TWLGVWGVRT MQARGFGSDQ SENVDRGAGS IREAGGAFGK REQAEEERYF RAQSREQLAA LKKHHEEEIV HHKKEIERLQ KEIERHKQKI KMLKHDD (1-106 aa encoded by BC009677)
Target Information
Complex V, also called F1F0 ATPase or ATP synthase is extremely conserved through evolution and can be found in plants, fungi, bacteria, and animals. The ATP synthase enzyme is a transmembrane protein responsible for driving the reversible reaction from ADP + phosphate to ATP, in oxidative phosphorylation, and as a proton pumping ATPase. This reaction is accomplished by a flux of protons across the membrane as a result of electron transfer. The enzyme was thought to be localized exclusively to mitochondria; however, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells. The ATP synthase protein has two main sections; the F1 ATP-ase (soluble) and the F0 ATP-ase (membrane embedded). The F1 section consists of the alpha, beta, gamma, delta, and epsilon subunits; while the F0 consists of a, b, and c subunits. The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mitochondrial DNA while the other subunits are nuclearly encoded. Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP synthase F1 subunit epsilon; ATP synthase inhibitor protein; ATPase inhibitor protein; ATPase inhibitor, mitochondrial; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase
Gene Aliases: ATP5IF1; ATPI; ATPIF1; ATPIP; IP
UniProt ID: (Human) Q5JXL8
Entrez Gene ID: (Human) 93974
angiogenesis
negative regulation of endothelial cell proliferation
generation of precursor metabolites and energy
heme biosynthetic process
folic acid-containing compound biosynthetic process
erythrocyte differentiation
negative regulation of ATPase activity
tetrahydrofolate interconversion
protein homooligomerization
protein homotetramerization
negative regulation of hydrolase activity
mitochondrial depolarization
reactive oxygen species metabolic process
mitophagy in response to mitochondrial depolarization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of protein targeting to mitochondrion
regulation of ATP metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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