Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 19787-1-AP) (ATR antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ATR Antibody in Immunoprecipitation (IP)

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Product Details

19787-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1,000

View 21 publications 21 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

42 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody can recognize all the isoform of ATR.

Target Information

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3-related protein; atr; ATR serine/threonine kinase; EC 2.7.11.1; FRAP-related protein-1; kinase ATR; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; TEM8; unnamed protein product

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Gene Aliases: FCTCS; FRP1; MEC1; SCKL; SCKL1

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UniProt ID: (Human) Q13535

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Entrez Gene ID: (Human) 545, (Mouse) 245000

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Function(s)

protein kinase activity protein serine/threonine kinase activity protein binding kinase activity MutLalpha complex binding MutSalpha complex binding histone H2AXS139 kinase activity protein serine kinase activity

Process(es)

DNA damage checkpoint G2/M transition of mitotic cell cycle telomere maintenance DNA replication DNA repair double-strand break repair chromatin remodeling protein phosphorylation cellular response to DNA damage stimulus nuclear envelope organization embryo implantation negative regulation of DNA replication response to mechanical stimulus replication fork processing positive regulation of telomere maintenance via telomerase cellular response to UV positive regulation of DNA damage response, signal transduction by p53 class mediator mitotic G2/M transition checkpoint nuclear envelope disassembly chromosome organization protein localization to chromosome, telomeric region cellular response to gamma radiation replicative senescence establishment of RNA localization to telomere DNA strand resection involved in replication fork processing positive regulation of telomerase catalytic core complex assembly protein localization to site of double-strand break regulation of double-strand break repair response to xenobiotic stimulus interstrand cross-link repair response to arsenic-containing substance regulation of cellular response to stress establishment of macromolecular complex localization to telomere regulation of cellular response to heat

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATR Polyclonal Antibody

ATR Antibody (19787-1-AP) in IHC (P)

Product Details

19787-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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