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Invitrogen
ATR Polyclonal Antibody
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Product Details
PA5149972
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Ataxia Telangiectasia And Rad3 Related Protein (ATR) (Ala2353-Met2644)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3 related; Ataxia telangiectasia and Rad3-related protein; ATR serine/threonine kinase; EC 2.7.11.1; FRAP-related protein 1; FRAP-related protein-1; kinase ATR; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; Serine/threonine-protein kinase ATR; TEM8
Gene Aliases: ATR; FCTCS; FRP1; MEC1; SCKL; SCKL1
UniProt ID: (Human) Q13535
Entrez Gene ID: (Human) 545, (Mouse) 245000, (Rat) 685055
DNA binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
MutLalpha complex binding
MutSalpha complex binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
protein dimerization activity
molecular_function
non-receptor serine/threonine protein kinase
protein modifying enzyme
DNA damage checkpoint
DNA replication
DNA repair
cellular response to DNA damage stimulus
cell cycle
multicellular organism development
negative regulation of DNA replication
peptidyl-serine phosphorylation
positive regulation of telomere maintenance via telomerase
cellular response to UV
interstrand cross-link repair
response to drug
positive regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
protein localization to chromosome, telomeric region
cellular response to gamma radiation
replicative senescence
establishment of RNA localization to telomere
establishment of macromolecular complex localization to telomere
regulation of cellular response to heat
regulation of signal transduction by p53 class mediator
positive regulation of telomerase catalytic core complex assembly
double-strand break repair via homologous recombination
protein phosphorylation
phosphorylation
regulation of protein binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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