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OriGene
ATR Polyclonal Antibody
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FIGURE: 1 / 2
ATR Antibody (TA890100) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ATR (RC224837, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ATR rabbit polyclonal antibody.
Product Details
TA890100
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human ATR
Conjugate
Form
Liquid
Concentration
1.36 mg/mL
Amount
136 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; Ataxia telangiectasia and Rad3-related protein; atr; ATR serine/threonine kinase; EC 2.7.11.1; FRAP-related protein 1; FRAP-related protein-1; kinase ATR; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; Serine/threonine-protein kinase ATR; TEM8
Gene Aliases: ATR; FCTCS; FRP1; MEC1; SCKL; SCKL1
UniProt ID: (Human) Q13535
Entrez Gene ID: (Human) 545, (Mouse) 245000
nucleotide binding
DNA binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
MutLalpha complex binding
MutSalpha complex binding
histone H2AXS139 kinase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
protein dimerization activity
non-receptor serine/threonine protein kinase
protein modifying enzyme
DNA damage checkpoint
G2/M transition of mitotic cell cycle
telomere maintenance
nucleobase-containing compound metabolic process
DNA replication
DNA repair
double-strand break repair
chromatin remodeling
cellular response to DNA damage stimulus
nuclear envelope organization
negative regulation of DNA replication
response to xenobiotic stimulus
response to mechanical stimulus
replication fork processing
positive regulation of telomere maintenance via telomerase
cellular response to UV
interstrand cross-link repair
positive regulation of DNA damage response, signal transduction by p53 class mediator
mitotic G2/M transition checkpoint
response to arsenic-containing substance
nuclear envelope disassembly
protein localization to chromosome, telomeric region
cellular response to gamma radiation
regulation of cellular response to stress
replicative senescence
establishment of RNA localization to telomere
establishment of macromolecular complex localization to telomere
DNA strand resection involved in replication fork processing
regulation of cellular response to heat
positive regulation of telomerase catalytic core complex assembly
protein localization to site of double-strand break
regulation of double-strand break repair
double-strand break repair via homologous recombination
protein phosphorylation
phosphorylation
peptidyl-serine phosphorylation
regulation of protein binding
protein autophosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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