PA1-519 detects human and mouse ATRIP.
PA1-519 has been successfully used in Western blot, immunoprecipitation and immunofluorescence procedures. By Western blot, this antibody detects an ~ 86 kDa protein from human HeLa cells.
PA1-519 antigen corresponds to amino acids 1-182 of human ATRIP
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR-interacting protein; Three prime repair exonuclease 1; TREX1
Gene Aliases: 6620401K05Rik; AGS1; ATRIP