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Bethyl Laboratories
ATRX Polyclonal Antibody
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Product Details
A301-045A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 2442 and the C-terminus (residue 2492) of human alpha thalassemia/mental retardation syndrome X-linked.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
Target Information
ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase ATRX; ATRX; helicase 2; RP5-875J14.1; Transcriptional regulator ATRX; unnamed protein product; X-linked helicase II; X-linked nuclear protein; XNP; Znf-HX
Gene Aliases: ATRX; JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX
UniProt ID: (Human) P46100
Entrez Gene ID: (Human) 546
meiotic spindle organization
DNA repair
chromatin organization
nucleosome assembly
chromatin remodeling
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
spermatogenesis
regulation of cell cycle process
positive regulation of nuclear cell cycle DNA replication
DNA damage response, signal transduction by p53 class mediator
forebrain development
replication fork processing
telomeric heterochromatin assembly
positive regulation of telomere maintenance
regulation of chromosome organization
post-embryonic forelimb morphogenesis
multicellular organism growth
positive regulation of transcription from RNA polymerase II promoter
Sertoli cell development
chromosome organization involved in meiotic cell cycle
protein localization to chromosome, telomeric region
seminiferous tubule development
cellular response to hydroxyurea
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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