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AVPR1B/AVP Receptor V3 Polyclonal Antibody
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Product Details
BS-11800R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human AVP Receptor V3, amino acids 23-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antidiuretic hormone receptor 1b; arginine vasopressin receptor 3; arginine vasopressin type 1b receptor; AVPR V1b; AVPR V3; pituitary vasopressin receptor 3; V1B receptor; V1bR; V3/V1b pituitary vasopressin receptor; Vasopressin V1b receptor; Vasopressin V3 receptor
Gene Aliases: AVPR1B; AVPR3; V1bR; V3/V1b; VIBR; VPR3
UniProt ID: (Human) P47901, (Mouse) Q9WU02
Entrez Gene ID: (Human) 553, (Mouse) 26361, (Rat) 29462
regulation of systemic arterial blood pressure by vasopressin
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of blood pressure
cellular response to hormone stimulus
regulation of cell proliferation
positive regulation of MAPK cascade
positive regulation of vasoconstriction
viral entry into host cell
positive regulation of inositol phosphate biosynthetic process
positive regulation of arachidonic acid secretion
transport across blood-brain barrier
response to peptide
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of glutamate secretion
positive regulation of cellular pH reduction
hyperosmotic salinity response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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