Proteintech

AXIN1 Polyclonal Antibody

13 References
View all (25) AXIN1 antibodies

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AXIN1 Polyclonal Antibody

Product Details

16541-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 11 publications 11 publications

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AXIN1 Fusion Protein Ag9858 (1-351 aa encoded by BC044648)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibody raised against the N-terminus of human AXIN1.

Immunogen sequence: MNIQEQGFP LDLGASFTED APRPPVPGEE GELVSTDPRP ASYSFCSGKG VGIKGETSTA TPRRSDLDLG YEPEGSASPT PPYLKWAESL HSLLDDQDGI SLFRTFLKQE GCADLLDFWF ACTGFRKLEP CDSNEEKRLK LARAIYRKYI LDNNGIVSRQ TKPATKSFIK GCIMKQLIDP AMFDQAQTEI QATMEENTYP SFLKSDIYLE YTRTGSESPK VCSDQSSGSG TGKGISGYLP TLNEDEEWKC DQDMDEDDGR DAAPPGRLPQ KLLLETAAPR VSSSRRYSEG REFRYGSWRE PVNPYYVNAG YALAPATSAN DSEQQSLSSD ADTLSLTDSS VDGIPPYRIR KQ (1-351 aa encoded by BC044648)

Target Information

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; protein phosphatase 1, regulatory subunit 49

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Gene Aliases: AXIN; AXIN1; PPP1R49

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UniProt ID: (Human) O15169

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Entrez Gene ID: (Human) 8312

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Function(s)
signal transducer activity GTPase activator activity protein binding beta-catenin binding enzyme binding protein kinase binding receptor signaling complex scaffold activity ubiquitin protein ligase binding protein complex scaffold identical protein binding protein homodimerization activity SMAD binding armadillo repeat domain binding I-SMAD binding scaffold/adaptor protein
Process(es)
optic placode formation positive regulation of protein phosphorylation apoptotic process activation of JUN kinase activity determination of left/right symmetry cell death dorsal/ventral axis specification positive regulation of peptidyl-threonine phosphorylation Wnt signaling pathway forebrain anterior/posterior pattern specification Wnt-activated signaling pathway involved in forebrain neuron fate commitment negative regulation of Wnt signaling pathway olfactory placode formation cytoplasmic microtubule organization positive regulation of protein ubiquitination activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation negative regulation of transcription elongation from RNA polymerase II promoter regulation of catenin import into nucleus proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of GTPase activity cellular protein complex assembly negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of JNK cascade embryonic eye morphogenesis axial mesoderm formation positive regulation of ubiquitin-protein transferase activity muscle cell development canonical Wnt signaling pathway embryonic skeletal joint morphogenesis canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation cellular response to organic cyclic compound negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway beta-catenin destruction complex assembly beta-catenin destruction complex disassembly positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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