Search
Proteintech
AXIN1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
16541-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AXIN1 Fusion Protein Ag9858 (1-351 aa encoded by BC044648)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibody raised against the N-terminus of human AXIN1.
Immunogen sequence: MNIQEQGFP LDLGASFTED APRPPVPGEE GELVSTDPRP ASYSFCSGKG VGIKGETSTA TPRRSDLDLG YEPEGSASPT PPYLKWAESL HSLLDDQDGI SLFRTFLKQE GCADLLDFWF ACTGFRKLEP CDSNEEKRLK LARAIYRKYI LDNNGIVSRQ TKPATKSFIK GCIMKQLIDP AMFDQAQTEI QATMEENTYP SFLKSDIYLE YTRTGSESPK VCSDQSSGSG TGKGISGYLP TLNEDEEWKC DQDMDEDDGR DAAPPGRLPQ KLLLETAAPR VSSSRRYSEG REFRYGSWRE PVNPYYVNAG YALAPATSAN DSEQQSLSSD ADTLSLTDSS VDGIPPYRIR KQ (1-351 aa encoded by BC044648)
Target Information
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; contains RGS domain and Daughterless similarity; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; protein phosphatase 1, regulatory subunit 49
Gene Aliases: AXIN; AXIN1; CMDOH; PPP1R49
UniProt ID: (Human) O15169
Entrez Gene ID: (Human) 8312
p53 binding
protein binding
beta-catenin binding
enzyme binding
protein kinase binding
protein domain specific binding
ubiquitin protein ligase binding
signaling adaptor activity
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activator activity
SMAD binding
binding, bridging
armadillo repeat domain binding
I-SMAD binding
R-SMAD binding
protein serine/threonine kinase binding
protein binding, bridging involved in substrate recognition for ubiquitination
protein polyubiquitination
in utero embryonic development
nucleocytoplasmic transport
apoptotic process
sensory perception of sound
dorsal/ventral axis specification
dorsal/ventral pattern formation
negative regulation of gene expression
Wnt signaling pathway
protein catabolic process
negative regulation of Wnt signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
cytoplasmic microtubule organization
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of transcription elongation from RNA polymerase II promoter
post-anal tail morphogenesis
proteasome-mediated ubiquitin-dependent protein catabolic process
epigenetic programming in the zygotic pronuclei
negative regulation of fat cell differentiation
positive regulation of protein catabolic process
positive regulation of JNK cascade
axial mesoderm development
axial mesoderm formation
cell development
negative regulation of protein metabolic process
canonical Wnt signaling pathway
head development
regulation of canonical Wnt signaling pathway
protein-containing complex assembly
negative regulation of canonical Wnt signaling pathway
beta-catenin destruction complex assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support