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Proteintech
AXL Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13196-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AXL Fusion Protein Ag3898 (545-894 aa encoded by BC032229)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects a single band at 140 kDa, which is considered to represent the auto-phosphorylated form of endogenous Axl.
Immunogen sequence: GEFGAVMEG QLNQDDSILK VAVKTMKIAI CTRSELEDFL SEAVCMKEFD HPNVMRLIGV CFQGSERESF PAPVVILPFM KHGDLHSFLL YSRLGDQPVY LPTQMLVKFM ADIASGMEYL STKRFIHRDL AARNCMLNEN MSVCVADFGL SKKIYNGDYY RQGRIAKMPV KWIAIESLAD RVYTSKSDVW SFGVTMWEIA TRGQTPYPGV ENSEIYDYLR RGNRLKQPAD CLDGLYALMS RCWELNPQDR PSFTELREDL ENTLKALPPA QEPDEILYVN MDEGGGYPEP PGAAGGADPP TQPDPKDSCS CLTAAEVHPA GRYVLCPSTT PSPAQPADRG SPAAPGQEDG A (545-894 aa encoded by BC032229)
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adhesion-related kinase; AXL oncogene; AXL transforming sequence/gene; AZF1; oncogene AXL; putative tyrosine kinase receptor; sAXL; soluble AXL; ufo; ufo oncogene homolog; unnamed protein product
Gene Aliases: ARK; AXL3; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530, (Mouse) Q00993
Entrez Gene ID: (Human) 558, (Mouse) 26362
natural killer cell differentiation
negative regulation of cytokine production
positive regulation of cytokine-mediated signaling pathway
phagocytosis
signal transduction
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
positive regulation of signal transduction
cell migration
platelet activation
negative regulation of interferon-gamma production
positive regulation of natural killer cell differentiation
cellular response to interferon-alpha
negative regulation of apoptotic process
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
cell maturation
positive regulation of pinocytosis
regulation of lymphocyte activation
positive regulation of protein kinase B signaling
cellular response to lipopolysaccharide
dendritic cell differentiation
mononuclear cell differentiation
positive regulation of viral life cycle
negative regulation of dendritic cell apoptotic process
neuron migration
blood vessel remodeling
inflammatory response
gamete generation
spermatogenesis
forebrain cell migration
cell differentiation
negative regulation of tumor necrosis factor production
secretion by cell
erythrocyte homeostasis
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
negative regulation of neuron apoptotic process
negative regulation of lymphocyte activation
vagina development
cellular response to hydrogen peroxide
neutrophil clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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