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Abl2 Antibody (PA5-27926) in WB
Western Blot using Abl2 Polyclonal Antibody (Product # PA5-27926). Sample (30 µg of whole cell lysate). Lane A: IMR32. 5% SDS PAGE. Abl2 Polyclonal Antibody (Product # PA5-27926) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-27926
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 55 and 470 of Human ABL2
Conjugate
Form
Liquid
Concentration
0.77 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545402
Product Specific Information
Recommended positive controls: IMR32.^M
^M
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (97%), Xenopus laevis (96%), Bovine (99%).^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2
Gene Aliases: ABL2; ABLL; ARG
UniProt ID: (Human) P42684
Entrez Gene ID: (Human) 27
cellular protein modification process
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
positive regulation of phospholipase C activity
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton organization
regulation of endocytosis
regulation of cell adhesion
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
positive regulation of oxidoreductase activity
cellular response to retinoic acid
regulation of cell motility
regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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