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Invitrogen
Acinus Polyclonal Antibody
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FIGURE: 1 / 4
Acinus Antibody (PA5-17344) in ICC/IF
Immunofluorescence analysis of ACIN1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Acinus Polyclonal Antibody (Product # PA5-17344) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32731), (1:25... View More
Product Details
PA5-17344
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Ala835 of Acinus
Conjugate
Form
Liquid
Concentration
35.1 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
ACINUS (apoptotic chromatin condensation inducer in the nucleus) is an induced of chromatin condensation. ACINUS is cleaved by caspase-3 and an additional unknown protease generating a small active peptide, p17, which causes chromatin condensation in vitro when it is added to purified nuclei. ACINUS also induces apoptotic chromatin condensation in cells. ACINUS is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acinus; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; functional spliceosome-associated protein 152
Gene Aliases: 2610036I19Rik; 2610510L13Rik; ACIN1; ACINUS; acinusL; acinusS; ACN; C79325; fSAP152; KIAA0670; mKIAA0670
UniProt ID: (Human) Q9UKV3, (Mouse) Q9JIX8
Entrez Gene ID: (Human) 22985, (Mouse) 56215, (Rat) 305884
positive regulation of defense response to virus by host
mRNA processing
cellular component disassembly involved in execution phase of apoptosis
RNA splicing
erythrocyte differentiation
apoptotic chromosome condensation
positive regulation of monocyte differentiation
mitophagy in response to mitochondrial depolarization
xenophagy
apoptotic process
regulation of autophagy
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of mRNA splicing, via spliceosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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