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Invitrogen

Actin Polyclonal Antibody

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View all (19) Actin antibodies

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Actin Polyclonal Antibody

Product Details

PA5-11571

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-
Product Specifications

Species Reactivity

Human

Published species

Plant

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 189-218 amino acids from the central region of human Actin (ACTB/ACTC)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

800 µg

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2223355

Product Specific Information

This antibody is predicted to react with bovine, chicken, canine, equine, hamster, mouse, porcine, non-human primate, rat, rabbit and Xenopus, yeast and zebrafish based on sequence homology.

Target Information

Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ACT2; ACTA1; ACTA2; ACTC; ACTG2; actin 2; actin 7; Actin is a protein with a high degree of evolutionary conservation that undergoes polymerization to generate filaments, which subsequently assemble into interconnected networks within the cytoplasm of cells.; actin, alpha 2, smooth muscle, aorta; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; Actin, aortic smooth muscle; Actin, cytoplasmic 1; Actin, cytoplasmic 2; actin, gamma 2, smooth muscle, enteric; Actin, gamma-enteric smooth muscle; actin-like protein; alpha-actin; Alpha-actin-1; Alpha-actin-2; Alpha-actin-3; Alpha-cardiac actin; alpha-sma; AtACT7; Atcb; beta cytoskeletal actin; Beta-actin; Cell growth-inhibiting gene 46 protein; cytoskeletal gamma-actin; DEFORMED ROOT HAIRS 1; DER1; ENHANCER OF LRX1 2; ENL2; epididymis luminal protein 176; FIZ2; FRIZZY AND KINKED SHOOTS 2; Gamma-2-actin; Gamma-actin; GIG46; I(2)-actin; LIGHT STRESS-REGULATED 2; LSR2; MYH9.2; MYH9_2; nemaline myopathy type 3; pan actin; PS1TP5-binding protein 1; RP5-1068B5.2; Smooth muscle gamma-actin; unnamed protein product

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Gene Aliases: ACT; ACTA; ACTA1; ACTA2; ACTA3; ACTB; ACTC; ACTC1; ACTE; ACTG; ACTG1; ACTG2; ACTL3; ACTSA; ACTSG; ACTVS; ASD5; ASMA; BKRNS; BNS; BRWS1; CFTD; CFTD1; CFTDM; CMD1R; CMH11; CMYO2A; CMYO2B; CMYO2C; CMYP2A; CMYP2B; CMYP2C; CSMH; DDS1; DFNA20; DFNA26; GIG46; HEL-176; LVNC4; MMIHS5; MPFD; NEM1; NEM2; NEM3; PS1TP5BP1; SHPM; SMDYS; THC8; VSCM; VSCM1

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UniProt ID: (Human) P68133, (Human) P62736, (Human) P60709, (Human) P68032, (Human) P63261, (Human) P63267

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Entrez Gene ID: (Human) 58, (Human) 59, (Human) 60, (Human) 70, (Human) 71, (Human) 72

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Function(s)
nucleotide binding structural constituent of cytoskeleton protein binding ATP binding hydrolase activity myosin binding ADP binding protein kinase binding ATPase activity kinesin binding nitric-oxide synthase regulator activity Tat protein binding nucleosomal DNA binding identical protein binding tau protein binding nitric-oxide synthase binding structural constituent of postsynaptic actin cytoskeleton transporter regulator activity microfilament motor activity profilin binding ubiquitin protein ligase binding
Process(es)
actin filament organization response to xenobiotic stimulus positive regulation of gene expression actin filament-based movement skeletal muscle thin filament assembly actomyosin structure organization actin-myosin filament sliding negative regulation of apoptotic process response to ethanol cardiac myofibril assembly cardiac muscle tissue morphogenesis heart contraction cardiac muscle contraction cytoplasmic actin-based contraction involved in cell motility mesenchyme migration angiogenesis morphogenesis of a polarized epithelium axonogenesis positive regulation of cell migration maintenance of blood-brain barrier sarcomere organization cell motility regulation of stress fiber assembly regulation of focal adhesion assembly platelet aggregation cellular response to interferon-gamma positive regulation of wound healing postsynaptic actin cytoskeleton organization tight junction assembly regulation of transepithelial transport regulation of synaptic vesicle endocytosis protein localization to bicellular tight junction chromatin remodeling regulation of transcription from RNA polymerase II promoter cytoskeleton organization establishment or maintenance of cell polarity positive regulation of cell proliferation substantia nigra development regulation of mitotic metaphase/anaphase transition adherens junction assembly regulation of apoptotic process apical protein localization positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated regulation of norepinephrine uptake positive regulation of norepinephrine uptake regulation of cell cycle regulation of G0 to G1 transition protein localization to adherens junction cellular response to cytochalasin B positive regulation of stem cell population maintenance regulation of protein localization to plasma membrane positive regulation of double-strand break repair via homologous recombination regulation of G1/S transition of mitotic cell cycle regulation of double-strand break repair positive regulation of double-strand break repair regulation of nucleotide-excision repair muscle contraction skeletal muscle fiber development regulation of blood pressure response to virus vascular smooth muscle contraction positive regulation of hepatic stellate cell migration positive regulation of hepatic stellate cell contraction positive regulation of ERK1 and ERK2 cascade cellular response to transforming growth factor beta stimulus juxtaglomerular apparatus development glomerular mesangial cell development positive regulation of hepatic stellate cell activation
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