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Activin A Receptor Type IC Polyclonal Antibody
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FIGURE: 1 / 3
Activin A Receptor Type IC Antibody (BS-5777R) in IHC (P)
Formalin-fixed and paraffin embedded human stomach labeled with Rabbit Anti ACTRIC/Activin A Receptor Type IC Polyclonal Antibody, Unconjugated (bs-5777R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
Product Details
BS-5777R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ACTRIC/Activin A Receptor Type IC, amino acids 21-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; acvr1c; acvr1c {ECO:0000312|EMBL:AAC52803.1}; ACVRLK2; ALK-7; ALK2; ALK7; protein kinase; FOP; sALK7a; alternatively spliced; sALK7b; alternatively spliced; SKR1; tALK7; alternatively spliced; TGF-beta type 1 receptor; TSRI
Gene Aliases: ACVR1C; ACVRLK7; Alk-7; ALK7; C230097P10; habrec1
UniProt ID: (Human) Q8NER5, (Rat) P70539, (Mouse) Q8K348
Entrez Gene ID: (Human) 130399, (Rat) 245921, (Mouse) 269275
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
ATP binding
kinase activity
activin receptor activity, type I
transferase activity
activin-activated receptor activity
growth factor binding
nodal binding
metal ion binding
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
SMAD binding
activin binding
BMP receptor binding
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
trophectodermal cell proliferation
response to dietary excess
protein phosphorylation
apoptotic process
transmembrane receptor protein serine/threonine kinase signaling pathway
nervous system development
response to glucose
lipid storage
insulin secretion
cell differentiation
apoptotic nuclear changes
regulation of cell migration
response to insulin
activin receptor signaling pathway
nodal signaling pathway
positive regulation of apoptotic process
negative regulation of insulin secretion
regulation of multicellular organismal process
cellular response to growth factor stimulus
apoptotic signaling pathway
transforming growth factor beta receptor superfamily signaling pathway
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
ovarian follicle development
in utero embryonic development
transforming growth factor beta receptor complex assembly
determination of left/right symmetry
response to organic cyclic compound
cerebellum development
hippocampus development
signal transduction by protein phosphorylation
midbrain development
response to lipid
response to drug
regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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