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Invitrogen

Adipolean variant Polyclonal Antibody, PeproTech®

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Adipolean variant Polyclonal Antibody, PeproTech®

Product Details

500-P205-50UG

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.2 µg/mL
-

ELISA (ELISA)

0.5-2.0 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived Recombinant Human gAcrp30/Adipolean Variant
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.1-1.0 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

RRID

AB_2929806

Product Specific Information

AA Sequence of recombinant protein: PGAEGPRGFP GIQGRKGEPG EGAYVYRSAF SVGLETYVTI PNMPIRFTKI FYNQQNHYDG STGKFHCNIP GLYYFAYHIT VYMKDVKVSL FKKDKAMLFT YDQYQENNVD QASGSVLLHL EVGDQVWLQV YGEGERNGLY ADNDNDSTFT GFLLYHDTN.

Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human gAcrp30/Adipolean Variant. Anti-Human gAcrp30/Adipolean Variant-specific antibody was purified by affinity chromatography employing an immobilized Human gAcrp30/Adipolean Variant matrix.

Sandwich ELISA: To detect Human gAcrp30/Adipolean Variant by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human gAcrp30/Adipolean Variant (500-P205Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human gAcrp30/Adipolean Variant.

Western Blot: To detect Human gAcrp30/Adipolean Variant by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human gAcrp30/Adipolean Variant is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Target Information

The gAcrp30 variant is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, Acrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. This naturally occurring variant of human gAcrp30/Adipolean is an 18.1 kDa protein, containing 14 extra amino acids extra at the N-terminus of human gAcrp30/Adipolean.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 30 kDa adipocyte complement-related protein; ACRP30; Adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; Adiponectin; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; apM-1; gAcrp30; Gelatin-binding protein; gelatin-binding protein 28; unnamed protein product

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Gene Aliases: ACDC; ACRP30; ADIPOQ; ADIPQTL1; ADPN; APM-1; APM1; GBP28

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UniProt ID: (Human) Q15848

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Entrez Gene ID: (Human) 9370

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Function(s)
receptor binding cytokine activity hormone activity extracellular matrix structural constituent protein binding sialic acid binding identical protein binding protein homodimerization activity protein serine/threonine kinase activator activity
Process(es)
response to hypoxia positive regulation of protein phosphorylation glucose metabolic process generation of precursor metabolites and energy fatty acid beta-oxidation response to nutrient circadian rhythm response to xenobiotic stimulus response to bacterium response to sucrose response to glucose positive regulation of signal transduction gene expression negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process response to activity fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation response to nutrient levels negative regulation of protein autophosphorylation negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity response to ethanol negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of gluconeogenesis negative regulation of blood pressure negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion negative regulation of receptor-mediated endocytosis negative regulation of inflammatory response negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation response to glucocorticoid negative regulation of cholesterol import negative regulation of ERK1 and ERK2 cascade response to linoleic acid detection of oxidative stress cellular response to cAMP cellular response to xenobiotic stimulus positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus protein localization to plasma membrane negative regulation of intracellular protein transport positive regulation of cold-induced thermogenesis negative regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction negative regulation of receptor binding negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of cAMP-dependent protein kinase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration
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