Keep as concentrated solution.
Positive Control: MCF-7, Mouse white adipose tissue, mouse muscle, rat muscle.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Adiponectin (also known as 30- kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACDCR1 antibody; adiponectin receptor 1 antibody; Adiponectin receptor protein 1; adiponectin receptor protein 1 antibody; ADIPOR1 antibody; CGI45 antibody; FLJ25385 antibody; FLJ42464 antibody; PAQR1 antibody; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I; progestin and adipoQ receptor family member I antibody; TESBP1A antibody
Gene Aliases: 2810031L11Rik; ACDCR1; ADIPOR1; CGI-45; CGI45; PAQR1; Parq1; TESBP1A
Molecular Function: receptor