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Proteintech
Adiponectin receptor Polyclonal Antibody
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Product Details
14361-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Hamster,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Adiponectin receptor Fusion Protein Ag5744 (1-147 aa encoded by BC051858)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody raised against 1-147aa of human AdipoR2 may cross-react with AdipoR1.
Immunogen sequence: MNEPTENRL GCSRTPEPDI RLRKGHQLDG TRRGDNDSHQ GDLEPILEAS VLSSHHKKSS EEHEYSDEAP QEDEGFMGMS PLLQAHHAME KMEEFVCKVW EGRWRVIPHD VLPDWLKDND FLLHGHRPPM PSFRACFKSI FRIHTETG (1-147 aa encoded by BC051858)
Target Information
Adiponectin (also known as 30- kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adiponectin receptor protein 1; Adiponectin receptor protein 2; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member I; Progestin and adipoQ receptor family member II; unnamed protein product
Gene Aliases: 1110001I14Rik; 2810031L11Rik; ACDCR1; ACDCR2; ADCR2; ADIPOR1; ADIPOR2; AI115388; AW554121; CGI-45; CGI45; D6Ucla1e; PAQR1; PAQR2; Parq1; Parq2; TESBP1A
UniProt ID: (Human) Q96A54, (Human) Q86V24, (Mouse) Q91VH1, (Mouse) Q8BQS5
Entrez Gene ID: (Human) 51094, (Human) 79602, (Rat) 289036, (Mouse) 72674, (Rat) 312670, (Mouse) 68465
lipid metabolic process
fatty acid metabolic process
hormone-mediated signaling pathway
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
regulation of glucose metabolic process
regulation of lipid metabolic process
fatty acid oxidation
negative regulation of cell growth
leptin-mediated signaling pathway
adiponectin-activated signaling pathway
glucose homeostasis
negative regulation of JAK-STAT cascade
positive regulation of JAK-STAT cascade
positive regulation of insulin receptor signaling pathway
positive regulation of cold-induced thermogenesis
negative regulation of NIK/NF-kappaB signaling
vascular wound healing
heart development
female pregnancy
response to nutrient
positive regulation of glucose import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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