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Invitrogen
AgRP Polyclonal Antibody
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FIGURE: 1 / 3
AgRP Antibody (PA5-78739) in IHC (P)
Immunohistochemistry analysis of AgRP on paraffin-embedded mouse lung tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with AgRP polyclonal antibody (Product# PA5-78739) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Development... View More
Product Details
PA5-78739
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived mouse AGRP recombinant protein (Position: S82-T131).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - IHC: mouse lung tissue, rat lung tissue, rat testis tissue.
Target Information
Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: agouti related protein; agouti related protein homolog; Agouti-related protein; orexigenic neuropeptide
Gene Aliases: AGRP; AGRT; ART; ASIP2
UniProt ID: (Human) O00253, (Mouse) P56473
Entrez Gene ID: (Human) 181, (Mouse) 11604, (Rat) 25582
neuropeptide signaling pathway
circadian rhythm
feeding behavior
adult feeding behavior
hormone-mediated signaling pathway
response to insulin
eating behavior
long-day photoperiodism
maternal process involved in female pregnancy
regulation of feeding behavior
positive regulation of feeding behavior
photoperiodism
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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