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Proteintech
AlaRS Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-17394
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AlaRS fusion protein Ag11294
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDSTLTASE IRQRFIDFFK RNEHTYVHSS ATIPLDDPTL LFANAGMNQF KPIFLNTIDP SHPMAKLSRA ANTQKCIRAG GKHNDLDDVG KDVYHHTFFE MLGSWSFGDY FKELACKMAL ELLTQEFGIP IERLYVTYFG GDEAAGLEAD LECKQIWQNL GLDDTKILPG NMKDNFWEMG DTGPCGPCSE IHYDRIGGRD AAHLVNQDDP NVLEIWNLVF IQYNREADGI LKPLPKKSID TGMGLERLVS VLQNKMSNYD TDLFVPYFEA IQKGTGARPY TGKVGAEDAD GIDMAYRVLA DHARTITVAL ADGGRPDNTG RGYVLRRILR RAVRYAHEKL NASRGFFATL V
Target Information
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E. coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alanine tRNA ligase 1, cytoplasmic; Alanine--tRNA ligase, cytoplasmic; Alanyl-tRNA synthetase; alanyl-tRNA synthetase, cytoplasmic; AlaRS; Protein lactyltransferase AARS1; Renal carcinoma antigen NY-REN-42; unnamed protein product
Gene Aliases: AARS; AARS1; CMT2N; DEE29; EIEE29; HDLS2; TTD8
UniProt ID: (Human) P49588
Entrez Gene ID: (Human) 16
tRNA binding
nucleotide binding
aminoacyl-tRNA editing activity
Ser-tRNA(Ala) hydrolase activity
nucleic acid binding
RNA binding
aminoacyl-tRNA ligase activity
alanine-tRNA ligase activity
ATP binding
zinc ion binding
amino acid binding
ligase activity
metal ion binding
peptide lactyltransferase (ATP-dependent) activity
tRNA modification
translation
tRNA aminoacylation for protein translation
alanyl-tRNA aminoacylation
tRNA processing
cerebellar Purkinje cell layer development
DNA damage response, signal transduction by p53 class mediator
hippo signaling
positive regulation of hippo signaling
tRNA aminoacylation
negative regulation of neuron apoptotic process
neuromuscular process controlling balance
neuromuscular process
neuron apoptotic process
aminoacyl-tRNA metabolism involved in translational fidelity
regulation of cytoplasmic translational fidelity
negative regulation of signal transduction by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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