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Invitrogen
Aldolase B Polyclonal Antibody
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Product Details
PA5-92047
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ALDOB (NP_0000262)
Conjugate
Form
Liquid
Concentration
1.59 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAHRFPALTQ EQKKELSEIA QSIVANGKGI LAADESVGTM GNRLQRIKVE NTEENRRQFR EILFSVDSSI NQSIGGVILF HETLYQKDSQ GKLFRNILKE KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VIPDGDHDLE; Positive Samples: LO2, K-562, MCF7, Mouse liver, Mouse kidney, Mouse skeletal muscle, Rat liver, Rat kidney, Mouse heart; Cellular Location: Cytoplasm, centriolar satellite, centrosome, cytoskeleton, microtubule organizing center
Target Information
Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aldolase 2; aldolase 2, B isoform; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; Fructose-bisphosphate aldolase B; Liver-type aldolase
Gene Aliases: ALDB; Aldo-2; ALDO2; ALDOB; BC016435; LIV10
UniProt ID: (Human) P05062, (Mouse) Q91Y97
Entrez Gene ID: (Human) 229, (Mouse) 230163, (Rat) 24190
liver development
fructose metabolic process
gluconeogenesis
glycolytic process
NADH oxidation
response to fructose
response to zinc ion
fructose 1,6-bisphosphate metabolic process
cellular response to extracellular stimulus
positive regulation of ATPase activity
cellular response to insulin stimulus
response to drug
response to starvation
response to amino acid
response to copper ion
response to glucocorticoid
response to cAMP
canonical glycolysis
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
vacuolar proton-transporting V-type ATPase complex assembly
response to interleukin-6
response to peptide hormone
response to carbohydrate
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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