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Product Details
41010-100UG
Product Specifications
Species Reactivity
Fruit fly,
Human
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Human Alien protein.
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alien homolog; Alien protein; alien-PA; alien-PB; alien-PD; alien-PE; CG9556-PA; CG9556-PB; CG9556-PD; CG9556-PE; COP9; COP9 complex homolog subunit 2; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; d-Alien; Dch2; drosophila COP9 signalosome homolog 2; JAB1-containing signalosome subunit 2; SD08021p; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
Gene Aliases: ALIEN; BcDNA:LD10463; CG9556; CH2; COPS2; CSN2; DCH2; Dmel\CG9556; Dmel_CG9556; SGN2; TRIP15
UniProt ID: (Human) P61201, (Fruit fly) Q94899
Entrez Gene ID: (Human) 9318, (Fruit fly) 34225
negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
signal transduction
cell proliferation
cullin deneddylation
neuron differentiation
skeletal muscle cell differentiation
negative regulation of nucleic acid-templated transcription
protein deneddylation
multicellular organism development
germ cell development
female germ-line stem cell population maintenance
negative regulation of transcription, DNA-templated
male germ-line cyst encapsulation
germarium-derived cystoblast division
protein stabilization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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