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PA1-4357 detects the alivin 1 protein in mouse and rat samples.
PA1-4357 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of ~63 and 66 kDa representing alivin 1 in mouse brain lysate.
The PA1-4357 immunogen is a synthetic peptide correspondiing to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. There is 81% sequence identity to human.
A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alivin 1; Alivin-1; AMIGO-2; amigo2; amigo2 {ECO:0000312|EMBL:AAO48951.1}; amphoterin induced gene 2; amphoterin induced gene and ORF 2; Amphoterin-induced protein 2; transmembrane protein AMIGO2
Gene Aliases: AI415330; Ali1; AMIGO-2; Amigo2; AW208913
UniProt ID: (Mouse) Q80ZD9, (Rat) Q7TNJ4
Entrez Gene ID: (Mouse) 105827, (Rat) 300186
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