This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: A2AP; Alpha 2 antiplasmin; Alpha 2 AP; ALPHA 2 PI; Alpha 2 plasmin inhibitor; Alpha-2-antiplasmin; Alpha-2-AP; Alpha-2-PI; Alpha-2-plasmin inhibitor; pigment epithelium derived factor; plasmin inhibitor alpha 2; PLI; serine (or cysteine) peptidase inhibitor, clade F, member 2; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serine (or cysteine) proteinase inhibitor, clade F, member 2; Serpin F2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; SERPINF2
Gene Aliases: A2AP; AAP; AI747498; ALPHA-2-PI; API; PLI; Serpimf2; SERPINF2