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Invitrogen
Alpha-2a Adrenergic Receptor Polyclonal Antibody
Product Details
PA5-114152
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal region of Human ADRA2A
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884667
Product Specific Information
Immunogen sequence: RRPERGPRGK GKARASQVKP GDSLPRRGPG ATGIGTPAAG PGEERVGAAK
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 92%; Dog: 85%; Guinea Pig: 79%; Human: 100%; Mouse: 79%; Pig: 85%; Rat: 79%
Target Information
Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; OTTHUMP00000058849
Gene Aliases: ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
UniProt ID: (Human) P08913
Entrez Gene ID: (Human) 150
alpha2-adrenergic receptor activity
protein binding
protein kinase binding
alpha-1B adrenergic receptor binding
alpha-2C adrenergic receptor binding
thioesterase binding
heterotrimeric G-protein binding
protein homodimerization activity
protein heterodimerization activity
epinephrine binding
norepinephrine binding
G-protein coupled receptor
positive regulation of cytokine production
acute inflammatory response
DNA replication
movement of cell or subcellular component
signal transduction
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
Ras protein signal transduction
Rho protein signal transduction
female pregnancy
positive regulation of cell proliferation
negative regulation of norepinephrine secretion
regulation of vasoconstriction
actin cytoskeleton organization
platelet activation
positive regulation of cell migration
negative regulation of cAMP biosynthetic process
activation of protein kinase activity
activation of protein kinase B activity
negative regulation of epinephrine secretion
cellular response to hormone stimulus
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
glucose homeostasis
positive regulation of potassium ion transport
positive regulation of MAP kinase activity
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of vasodilation
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
regulation of insulin secretion
intestinal absorption
thermoception
negative regulation of lipid catabolic process
positive regulation of membrane protein ectodomain proteolysis
negative regulation of calcium ion transport
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of uterine smooth muscle contraction
negative regulation of adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
phospholipase C-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
positive regulation of wound healing
negative regulation of calcium ion transmembrane transporter activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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