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Bethyl Laboratories
Alpha-Adducin Polyclonal Antibody
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FIGURE: 1 / 4
Alpha-Adducin Antibody (A303-714A) in IHC (P)
Detection of human Alpha-Adducin by immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Alpha-Adducin (Product # A303-714A) (lot 1) used at a dilution of 1:5,000 (0.2 µg/mL) (right) and (Product # A303-713A) (lot 1) used at a dilution of 1:5,000 (0.2 µg/mL) (left). Detection: DAB.
Product Details
A303-714A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 632 and 682 of human Adducin 1 (alpha).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; Alpha-adducin; beta Adducin; Beta-adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha
Gene Aliases: ADD1; ADDA
UniProt ID: (Human) P35611
Entrez Gene ID: (Human) 118
actin binding
structural molecule activity
calmodulin binding
transcription factor binding
spectrin binding
protein homodimerization activity
poly(A) RNA binding
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion
non-motor actin binding protein
cell morphogenesis
in utero embryonic development
cell volume homeostasis
hemoglobin metabolic process
actin cytoskeleton organization
erythrocyte differentiation
positive regulation of protein binding
multicellular organism growth
IRE1-mediated unfolded protein response
homeostasis of number of cells within a tissue
barbed-end actin filament capping
actin filament bundle assembly
transmembrane transport
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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