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Proteintech
Amphiphysin Polyclonal Antibody
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Product Details
13379-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Amphiphysin Fusion Protein Ag4204 (346-695 aa encoded by BC034376)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KKEETLLDL DFDPFKPEVT PAGSAGVTHS PMSQTLPWDL WTTSTDLVQP ASGGSFNGFT QPQDTSLFTM QTDQSMICNL AESEQAPPTE PKAEEPLAAV TPAVGLDLGM DTRAEEPVEE AVIIPGADAD AAVGTLVSAA EGAPGEEAEA ETATVPAGEG VSLEEAKIGT ETTEGAESAQ PEAEELEATV PQEKVIPSVV IEPASNHEEE GENEITIGAE PKETTEDAAP PGPTSETPEL ATEQKPIQDP QPTPSAPAMG AADQLASARE ASQELPPGFL YKVETLHDFE AANSDELTLQ RGDVVLVVPS DSEADQDAGW LVGVKESDWL QYRDLATYKG LFPENFTRRL D (346-695 aa encoded by BC034376)
Target Information
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471; unnamed protein product
Gene Aliases: AMPH; AMPH1
UniProt ID: (Human) P49418, (Rat) O08838, (Mouse) Q7TQF7
Entrez Gene ID: (Human) 273, (Rat) 60668, (Mouse) 218038
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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