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Invitrogen
Amylin Polyclonal Antibody
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Product Details
PA5-102889
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IAPP(Accession P10997), corresponding to amino acid residues F9-I59.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Amylin.
Target Information
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amylin; amylin peptide; amylin precursor; DAP; Diabetes-associated peptide; IAPP; Insulinoma amyloid peptide; Islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); Rabbit Anti-Amylin; unnamed protein product
Gene Aliases: DAP; IAP; IAPP
UniProt ID: (Human) P10997, (Mouse) P12968, (Rat) P12969
Entrez Gene ID: (Human) 3375, (Mouse) 15874, (Rat) 24476
apoptotic process
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of cell proliferation
positive regulation of gene expression
sensory perception of pain
osteoclast differentiation
negative regulation of protein complex assembly
protein destabilization
eating behavior
positive regulation of apoptotic process
positive regulation of MAPK cascade
bone resorption
negative regulation of osteoclast differentiation
negative regulation of bone resorption
positive regulation of calcium-mediated signaling
protein homooligomerization
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
calcitonin family receptor signaling pathway
amylin receptor signaling pathway
positive regulation of cAMP/PKA signal transduction
amylin receptor 1 signaling pathway
amylin receptor 2 signaling pathway
amylin receptor 3 signaling pathway
negative regulation of amyloid fibril formation
amyloid fibril formation
negative regulation of cell differentiation
glucose metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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