Search
Invitrogen
Angiostatin Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
Angiostatin Antibody (PA1-600) in ICC/IF
Immunofluorescent analysis of Angiostatin (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with an Angiostatin polyclonal antibody (Product # PA1-600) in 3% BS... View More
Product Details
PA1-600
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide: V(98) Y L S E C K T G I G N G Y R G T M S(116)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-600 detects recombinant human and mouse angiostatin.
PA1-600 has been successfully used in Western blot and ICC/IF procedures. By Western blot, this antibody detects a 50 kDa protein representing recombinant human angiostatin.
PA1-600 immunizing peptide corresponds to amino acid residues 98-116 from mouse angiostatin. This sequence is 95% and 84% conserved in rat and human angiostatin, respectively.
PA1-600 can be used with blocking peptide PEP-111.
Target Information
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: angiostatin; Microplasmin; plasmin; plasmin heavy chain A; plasmin light chain B; Plasminogen; unnamed protein product
Gene Aliases: AI649309; HAE4; Pg; PLG
UniProt ID: (Human) P00747, (Mouse) P20918
Entrez Gene ID: (Human) 5340, (Mouse) 18815
protease binding
endopeptidase activity
serine-type endopeptidase activity
receptor binding
protein binding
peptidase activity
serine-type peptidase activity
hydrolase activity
enzyme binding
kinase binding
protein domain specific binding
apolipoprotein binding
chaperone binding
protein antigen binding
serine protease
proteolysis
blood coagulation
hemostasis
negative regulation of cell proliferation
negative regulation of cell-substrate adhesion
protein processing
extracellular matrix disassembly
tissue regeneration
fibrinolysis
positive regulation of blood vessel endothelial cell migration
myoblast differentiation
muscle cell cellular homeostasis
tissue remodeling
interaction with symbiont
negative regulation of fibrinolysis
positive regulation of fibrinolysis
trophoblast giant cell differentiation
labyrinthine layer blood vessel development
mononuclear cell migration
trans-synaptic signaling by BDNF, modulating synaptic transmission
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of angiogenesis
proteolysis involved in cellular protein catabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support