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Proteintech

Angiotensinogen Polyclonal Antibody

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View all (45) Angiotensinogen antibodies

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Angiotensinogen Polyclonal Antibody

Product Details

23972-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Angiotensinogen Fusion Protein Ag21121 (1-485 aa encoded by BC011519)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRKRAPQSE MAPAGVSLRA TILCLLAWAG LAAGDRVYIH PFHLVIHNES TCEQLAKANA GKPKDPTFIP APIQAKTSPV DEKALQDQLV LVAAKLDTED KLRAAMVGML ANFLGFRIYG MHSELWGVVH GATVLSPTAV FGTLASLYLG ALDHTADRLQ AILGVPWKDK NCTSRLDAHK VLSALQAVQG LLVAQGRADS QAQLLLSTVV GVFTAPGLHL KQPFVQGLAL YTPVVLPRSL DFTELDVAAE KIDRFMQAVT GWKTGCSLTG ASVDSTLAFN TYVHFQGKMK GFSLLAEPQE FWVDNSTSVS VPMLSGMGTF QHWSDIQDNF SVTQVSFTES ACLLLIQPHY ASDLDKVEGL TFQQNSLNWM KKLSPRTIHL TMPQLVLQGS YDLQDLLAQA ELPAILHTEL NLQKLSNDRI RVGEVLNSIF FELEADEREP TESTQQLNKP EVLEVTLNRP FLFAVYDQSA TALHFLGRVA NPLSTA (1-485 aa encoded by B C011519)

Target Information

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; fetal-liver predominant transporter 1; pre-angiotensinogen; preangiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8; unnamed protein product

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Gene Aliases: AGT; ANHU; hFLT1; SERPINA8

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UniProt ID: (Human) P01019

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Entrez Gene ID: (Human) 183

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Function(s)
serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity superoxide-generating NADPH oxidase activator activity sodium channel regulator activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding receptor agonist activity
Process(es)
regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of blood vessel size by renin-angiotensin renal system process regulation of systemic arterial blood pressure by renin-angiotensin G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway cell-cell signaling regulation of blood pressure positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of macrophage derived foam cell differentiation response to muscle activity involved in regulation of muscle adaptation regulation of vasoconstriction positive regulation of superoxide anion generation low-density lipoprotein particle remodeling regulation of renal sodium excretion nitric oxide-cGMP-mediated signaling pathway angiotensin-activated signaling pathway regulation of cell proliferation vasoconstriction regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAP kinase activity positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation positive regulation of inflammatory response negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of protein kinase B signaling renal sodium ion absorption positive regulation of branching involved in ureteric bud morphogenesis positive regulation of cholesterol metabolic process regulation of blood vessel diameter positive regulation of angiotensin-activated signaling pathway regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly negative regulation of sodium ion transmembrane transport positive regulation of membrane hyperpolarization positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of gap junction assembly regulation of cardiac conduction response to angiotensin positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway
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