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Invitrogen

Angiotensinogen Polyclonal Antibody

Advanced Verification
2 Published Figures
1 Reference
View all (21) Angiotensinogen antibodies

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Angiotensinogen Polyclonal Antibody

Product Details

PA5-47888

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

5-15 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHO-derived recombinant mouse Serpin A8/Angiotensinogen Asp25-Val477
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609481

Product Specific Information

In direct ELISAs, approximately 24% cross-reactivity with recombinant human Angiotensinogen is observed, and less than 1% cross-reactivity with recombinant mouse (rm) Serpin A1, rmSerpin C1, and rmSerpin F2 is observed.

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Target Information

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: angiotensin I; angiotensin II; angiotensin ll; Angiotensinogen; angiotensinogen (PAT); Serpin A8

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Gene Aliases: Agt; AI265500; Ang; AngI; AngII; ANRT; Aogen; PAT; Serpina8

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UniProt ID: (Rat) P01015

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Entrez Gene ID: (Rat) 24179, (Mouse) 11606

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Function(s)
serine-type endopeptidase inhibitor activity hormone activity sodium channel regulator activity angiotensin receptor binding type 1 angiotensin receptor binding type 2 angiotensin receptor binding protease inhibitor
Process(es)
ovarian follicle rupture blood vessel development branching involved in ureteric bud morphogenesis kidney development regulation of systemic arterial blood pressure by circulatory renin-angiotensin angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin brain renin-angiotensin system renal system process angiotensin-mediated drinking behavior positive regulation of extracellular matrix constituent secretion cellular sodium ion homeostasis cell-matrix adhesion cell surface receptor signaling pathway G-protein coupled receptor signaling pathway activation of phospholipase C activity activation of NF-kappaB-inducing kinase activity female pregnancy aging excretion establishment of blood-nerve barrier regulation of blood pressure positive regulation of cell proliferation negative regulation of cell proliferation response to cold response to salt stress regulation of gene expression positive regulation of activation of JAK2 kinase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of gene expression positive regulation of cholesterol esterification negative regulation of endopeptidase activity regulation of norepinephrine secretion positive regulation of phosphatidylinositol 3-kinase signaling artery smooth muscle contraction response to muscle activity involved in regulation of muscle adaptation negative regulation of angiogenesis extracellular matrix organization negative regulation of cell growth peristalsis positive regulation of cellular protein metabolic process positive regulation of superoxide anion generation positive regulation of peptidyl-serine phosphorylation negative regulation of tissue remodeling catenin import into nucleus regulation of renal sodium excretion positive regulation of renal sodium excretion positive regulation of multicellular organism growth vasoconstriction vasodilation hormone metabolic process drinking behavior regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of blood pressure positive regulation of transcription, DNA-templated positive regulation of vasodilation positive regulation of organ growth astrocyte activation fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation cytokine secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation smooth muscle cell differentiation negative regulation of neurotrophin TRK receptor signaling pathway stress-activated MAPK cascade regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development positive regulation of protein tyrosine kinase activity ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of branching involved in ureteric bud morphogenesis positive regulation of protein kinase C activity regulation of extracellular matrix assembly positive regulation of membrane hyperpolarization positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of extrinsic apoptotic signaling pathway regulation of heart rate
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