Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Hamster (100%) Rat, Panda, Rabbit, Horse (90%) Bat (85%).
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
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Protein Aliases: AGTRL1; Angiotensin II receptor-like 1; Angiotensin receptor-like 1; Apelin receptor; APJ; APJ (apelin) receptor; APJ receptor; APJR; APLNR; G protein-coupled receptor APJ; G-protein coupled receptor APJ; G-protein coupled receptor HG11; HG11; HG11 orphan receptor
Gene Aliases: AGTRL1; APJ; APJR; APLNR; HG11
UniProt ID: (Human) P35414
Entrez Gene ID: (Human) 187