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Invitrogen
Arg3.1 Polyclonal Antibody
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Product Details
PA1-18301
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal residues of human Arg3.1.
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-18301 detects Arg3.1 from mouse and rat samples.
PA1-18301 has been successfully used in immunohistochemistry procedures.
The PA1-18301 immunogen is a synthetic peptide corresponding to the C-terminal residues of human Arg3.1, conjugated to Blue Carrier Protein. The sequence is 100% conserved in mouse and rat.
After reconstitution keep aliquots at -20°C, avoiding freeze/thaw cycles, or 4°C, with an appropriate antibacterial agent. Glycerol (1:1) may be added for an andditional stability.
Reconstitute with 100 µL of distilled water.
Target Information
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activity regulated cytoskeletal-associated protein; Activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; Activity-regulated gene 3.1 protein homolog; ARC; arc {ECO:0000312|RGD:62037}; ARC/ARG3.1; arg3.1; Arg3.1/ARC; Growth factor ARC; hArc; mArc
Gene Aliases: ARC; Arc3.1; Arg3.1; C86064; KIAA0278; mArc; rg3.1
UniProt ID: (Human) Q7LC44, (Mouse) Q9WV31, (Rat) Q63053
Entrez Gene ID: (Human) 23237, (Mouse) 11838, (Rat) 54323
endocytosis
cytoskeleton organization
multicellular organism development
endoderm development
anterior/posterior pattern specification
cell migration
regulation of cell morphogenesis
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
learning
regulation of neuronal synaptic plasticity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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