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Invitrogen
Aromatase Polyclonal Antibody
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FIGURE: 1 / 1
Aromatase Antibody (PA5-19633) in WB
Western blot analysis of Human Skeletal Muscle Tissue Lysate using Product # PA5-19633, Aromatase primary antibody at a dilution of 1 µg/mL. Blot treated with a secondary IR Dye680-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:10000.
Product Details
PA5-19633
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 450 to the C-terminus of Human Aromatase.
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Heat mediated antigen retrieval recommended prior to tissue staining.
This antibody is predicted to react with rabbit based on sequence homology.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aromatase; aromatase precursor (EC 1.14.14.1); CYPXIX; cytochrome P-450-Arom; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; unnamed protein product
Gene Aliases: ARO; ARO1; CPV1; CYAR; CYP19; CYP19A1; CYPXIX; P-450AROM
UniProt ID: (Dog) Q5QQX7, (Human) P11511
Entrez Gene ID: (Dog) 494003, (Human) 1588
iron ion binding
heme binding
aromatase activity
monooxygenase activity
steroid hydroxylase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
metal ion binding
estrogen 2-hydroxylase activity
oxygenase
oxidation-reduction process
negative regulation of chronic inflammatory response
lipid metabolic process
steroid biosynthetic process
estrogen biosynthetic process
androgen catabolic process
syncytium formation
androgen metabolic process
female gonad development
negative regulation of macrophage chemotaxis
sterol metabolic process
female genitalia development
mammary gland development
response to estradiol
uterus development
prostate gland growth
testosterone biosynthetic process
positive regulation of estradiol secretion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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