Immunogen sequence: MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG LLTGVVVDSG; Positive Samples: THP-1, 293T, HepG2, HeLa, C6, Mouse spleen, Mouse lung, Mouse brain, Rat kidney; Cellular Location: Cell projection, Cytoplasm, cytoskeleton
ARP2 (actin-related protein 2) is an ATP-binding component of the ARP2/3 complex - a multiprotein complex that mediates actin polymerization upon stimulation by the nucleation-promoting factor (NPF). The ARP2/3 complex mediates the formation of branched actin networks in the cytoplasm and provides the force for cell motility. The ARP2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.
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Protein Aliases: Actin-like protein 2; Actin-related protein 2; ARP2 actin-related protein 2 homolog
Gene Aliases: 4921510D23Rik; AA409782; ACTR2; ARP2; D6Ertd746e