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QED Bioscience
Atg4C Polyclonal Antibody
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Product Details
23002-100UG
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids at the N-terminus of human Atg4C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG4 autophagy 4 homolog C; ATG4 autophagy related 4 homolog C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; Autophagin-3; autophagy-related 4C; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; cysteine peptidase; Cysteine protease ATG4C; epididymis secretory sperm binding protein; FLJ14867; HsAPG4C; unnamed protein product
Gene Aliases: APG4-C; APG4C; ATG4C; AUTL1; AUTL3; HsAPG4C
UniProt ID: (Human) Q96DT6
Entrez Gene ID: (Human) 84938, (Rat) 313391
autophagosome assembly
mitophagy
proteolysis
autophagy
protein transport
protein processing
piecemeal microautophagy of nucleus
aggrephagy
protein delipidation
mitophagy
C-terminal protein lipidation
protein targeting to membrane
cellular response to nitrogen starvation
biological_process
nucleophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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