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Axin 2 Polyclonal Antibody

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Axin 2 Polyclonal Antibody

Product Details

BS-5717R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Axin 2, amino acids 331-430.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Axil; Axin like protein; Axin-2; Axin-like protein; AXIN2; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582

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Gene Aliases: Axi1; AXIL; AXIN2; Conductin; ODCRCS

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UniProt ID: (Human) Q9Y2T1, (Mouse) O88566, (Rat) O70240

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Entrez Gene ID: (Human) 8313, (Mouse) 12006, (Rat) 29134

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Function(s)
protein binding beta-catenin binding enzyme binding protein kinase binding ubiquitin protein ligase binding binding, bridging I-SMAD binding GTPase activator activity armadillo repeat domain binding scaffold/adaptor protein
Process(es)
osteoblast differentiation somitogenesis intramembranous ossification secondary heart field specification aortic valve morphogenesis mitral valve morphogenesis chondrocyte differentiation involved in endochondral bone morphogenesis protein localization cell proliferation negative regulation of cell proliferation dorsal/ventral axis specification positive regulation of epithelial to mesenchymal transition Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway bone mineralization regulation of mismatch repair positive regulation of proteasomal ubiquitin-dependent protein catabolic process osteoblast proliferation negative regulation of osteoblast proliferation odontogenesis proteasome-mediated ubiquitin-dependent protein catabolic process maintenance of DNA repeat elements positive regulation of fat cell differentiation negative regulation of osteoblast differentiation mRNA stabilization cell development response to steroid hormone canonical Wnt signaling pathway regulation of chondrocyte development regulation of centromeric sister chromatid cohesion cellular response to dexamethasone stimulus stem cell proliferation negative regulation of canonical Wnt signaling pathway regulation of extracellular matrix organization positive regulation of protein phosphorylation regulation of transcription, DNA-templated cell death positive regulation of cell death cellular protein localization regulation of catenin import into nucleus negative regulation of catenin import into nucleus termination of G-protein coupled receptor signaling pathway positive regulation of GTPase activity positive regulation of protein kinase activity cellular response to organic cyclic compound Wnt signaling pathway involved in somitogenesis negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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