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Axin1 Polyclonal Antibody
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Product Details
BS-21732R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Axin1 (301-400).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; contains RGS domain and Daughterless similarity; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; LA16c-314G4.3; MGC52315; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin
Gene Aliases: AI316800; AXIN; AXIN1; CMDOH; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49
UniProt ID: (Human) O15169, (Rat) O70239, (Mouse) O35625
Entrez Gene ID: (Human) 8312, (Rat) 79257, (Mouse) 12005
p53 binding
protein binding
beta-catenin binding
enzyme binding
protein kinase binding
protein domain specific binding
ubiquitin protein ligase binding
signaling adaptor activity
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activator activity
SMAD binding
binding, bridging
armadillo repeat domain binding
I-SMAD binding
R-SMAD binding
protein serine/threonine kinase binding
protein binding, bridging involved in substrate recognition for ubiquitination
signal transducer activity
GTPase activator activity
receptor binding
protein C-terminus binding
receptor signaling complex scaffold activity
protein complex scaffold
protein self-association
scaffold/adaptor protein
protein polyubiquitination
in utero embryonic development
nucleocytoplasmic transport
apoptotic process
sensory perception of sound
dorsal/ventral axis specification
dorsal/ventral pattern formation
negative regulation of gene expression
Wnt signaling pathway
protein catabolic process
negative regulation of Wnt signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
cytoplasmic microtubule organization
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of transcription elongation from RNA polymerase II promoter
post-anal tail morphogenesis
proteasome-mediated ubiquitin-dependent protein catabolic process
epigenetic programming in the zygotic pronuclei
negative regulation of fat cell differentiation
positive regulation of protein catabolic process
positive regulation of JNK cascade
axial mesoderm development
axial mesoderm formation
cell development
negative regulation of protein metabolic process
canonical Wnt signaling pathway
head development
regulation of canonical Wnt signaling pathway
protein-containing complex assembly
negative regulation of canonical Wnt signaling pathway
beta-catenin destruction complex assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
optic placode formation
regulation of protein phosphorylation
positive regulation of protein phosphorylation
activation of JUN kinase activity
determination of left/right symmetry
adult walking behavior
cell death
hemoglobin metabolic process
forebrain anterior/posterior pattern specification
Wnt-activated signaling pathway involved in forebrain neuron fate commitment
olfactory placode formation
activation of protein kinase activity
erythrocyte homeostasis
regulation of catenin import into nucleus
termination of G-protein coupled receptor signaling pathway
positive regulation of JUN kinase activity
positive regulation of GTPase activity
cellular protein complex assembly
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
embryonic eye morphogenesis
neurological system process
protein homooligomerization
positive regulation of ubiquitin-protein transferase activity
muscle cell development
embryonic skeletal joint morphogenesis
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
cellular response to organic cyclic compound
genetic imprinting
Wnt signaling pathway involved in somitogenesis
signal transduction
multicellular organism development
cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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