AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
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Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; LA16c-314G4.3; MGC52315; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin
Gene Aliases: AI316800; AXIN; AXIN1; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49
Molecular Function: scaffold/adaptor protein