PA5-28850 targets AXL in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28850 immunogen is recombinant protein fragment corresponding to a region within amino acids 469 and 848 of Human AXL.
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The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: AXL oncogene; AXL transforming sequence/gene; JTK11; oncogene AXL; Tyrosine-protein kinase receptor UFO; UFO
Gene Aliases: ARK; AXL; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530
Entrez Gene ID: (Human) 558