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Invitrogen

B4GALT5 Polyclonal Antibody

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B4GALT5 Polyclonal Antibody

Product Details

PA5-101461

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human B4GALT5(Accession O43286), corresponding to amino acid residues K323-N373.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2850896

Product Specific Information

Antibody detects endogenous levels of total B4GALT5.

Target Information

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 4-gal; b4Gal-T5; Beta-1,4-galactosyltransferase 5; beta-1,4-galactosyltransferase V; Beta-1,4-GalT II; beta-1,4-GalT IV; Beta-1,4-GalTase 5; beta-1.4-galactosyltransferase V; beta4-GalT IV; beta4Gal-T5; Glucosylceramide beta-1,4-galactosyltransferase; LacCer synthase; Lactosylceramide synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5

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Gene Aliases: 9430078I07Rik; AW049941; AW539721; B4Gal-T5; B4GALT5; BETA4-GALT-IV; beta4Gal-T5; beta4GalT-V; Bgt-5; gt-V

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UniProt ID: (Human) O43286, (Mouse) Q9JMK0

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Entrez Gene ID: (Human) 9334, (Mouse) 56336, (Rat) 362275

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Function(s)
N-acetyllactosamine synthase activity protein binding galactosyltransferase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity transferase activity transferase activity, transferring glycosyl groups metal ion binding alpha-1,6-mannosyltransferase activity alpha-1,2-mannosyltransferase activity mannosyltransferase activity alpha-1,3-mannosyltransferase activity alpha-1,3-galactosyltransferase activity UDP-glucose:glycoprotein glucosyltransferase activity glycolipid mannosyltransferase activity oligosaccharyl transferase activity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity fucosyltransferase activity O antigen polymerase activity lipopolysaccharide-1,6-galactosyltransferase activity cellulose synthase activity 9-phenanthrol UDP-glucuronosyltransferase activity 1-phenanthrol glycosyltransferase activity 9-phenanthrol glycosyltransferase activity 1,2-dihydroxy-phenanthrene glycosyltransferase activity phenanthrol glycosyltransferase activity beta-1,4-mannosyltransferase activity alpha-1,2-galactosyltransferase activity dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity lipopolysaccharide-1,5-galactosyltransferase activity dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity inositol phosphoceramide synthase activity glucosyltransferase activity alpha-(1->3)-fucosyltransferase activity alpha-(1->6)-fucosyltransferase activity indole-3-butyrate beta-glucosyltransferase activity salicylic acid glucosyltransferase (ester-forming) activity salicylic acid glucosyltransferase (glucoside-forming) activity benzoic acid glucosyltransferase activity chondroitin hydrolase activity dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity cytokinin 9-beta-glucosyltransferase activity glycosyltransferase
Process(es)
carbohydrate metabolic process protein glycosylation lipid metabolic process sphingolipid metabolic process glycoprotein biosynthetic process ganglioside biosynthetic process via lactosylceramide O-glycan processing central nervous system neuron axonogenesis central nervous system myelination poly-N-acetyllactosamine biosynthetic process regulation of protein stability positive regulation of embryonic development neuron maturation glycosylation carbohydrate derivative biosynthetic process
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