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B7H4 Polyclonal Antibody
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Product Details
BS-0673R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from Rat B7H4, amino acids 50-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7-H4; B7h.5; co-stimulator molecule; costimulatory receptor; FLJ22418; Immune costimulatory protein B7-H4; immunoglobulin superfamily; B7 family; Protein B7S1; RP11-229A19.4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; unnamed protein product; V-set domain containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; vtcn1; vtcn1 {ECO:0000312|EMBL:AAH95842.1}
Gene Aliases: B7-H4; B7h.5; B7H4; B7S1; B7X; BC032925; PRO1291; RGD1311204; UNQ659/PRO1291; VCTN1; VTCN1
UniProt ID: (Human) Q7Z7D3, (Rat) Q501W4, (Mouse) Q7TSP5
Entrez Gene ID: (Human) 79679, (Rat) 295322, (Mouse) 242122
response to protozoan
regulation of cytokine production
adaptive immune response
immune system process
positive regulation of interleukin-2 production
positive regulation of T cell proliferation
regulation of T cell proliferation
negative regulation of T cell proliferation
negative regulation of apoptotic process
T cell receptor signaling pathway
negative regulation of T cell activation
interleukin-4 secretion
interferon-gamma secretion
positive regulation of interleukin-2 secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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