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OriGene
BABAM1 Polyclonal Antibody
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Product Details
TA890052
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human BABAM1
Conjugate
Form
Liquid
Concentration
2.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of Rap80 interactions and targeting 40 kDa; Mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1 A complex; New component of the BRCA1-A complex; new component of the BRCAA1 A complex
Gene Aliases: 5430437P03Rik; BABAM1; C19orf62; HSPC142; MERIT40; NBA1
UniProt ID: (Human) Q9NWV8, (Mouse) Q3UI43, (Rat) Q5XIJ6
Entrez Gene ID: (Human) 29086, (Mouse) 68251, (Rat) 290631
DNA repair
double-strand break repair
cellular response to DNA damage stimulus
response to ionizing radiation
chromatin modification
G2 DNA damage checkpoint
positive regulation of DNA repair
protein K63-linked deubiquitination
double-strand break repair via nonhomologous end joining
mitotic nuclear division
covalent chromatin modification
cell division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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