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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide near the C-terminus of human BACE1|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%).
BACE1 is a member of the peptidase A1 protein family, and is expressed by neurons and astrocytes in the brain. BACE1 catalyzes the cleavage of beta APP at the extracellular, amino-terminal domain leading to the formation of amyloid beta peptide. Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicated with Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
APP beta-secretase; asp 2; ASP2; aspartyl protease 2; BACE; beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; HSPC104; memapsin-2; membrane-associated aspartic protease 2; transmembrane; transmembrane aspartic proteinase Asp2
ASP2; BACE; BACE1; HSPC104; KIAA1149