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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 44-59 of human BACE2.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.5-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In Western blot, this antibody detects a ~70 kDa band in human heart tissue lysate.
Accumulation of the amyloid-ß (Aß) plaque in the cerebral cortex isis a critical event in the pathogenesis of Alzheimer"e;s disease. Aß peptide is generated by proteolytic cleavage of the ß-amyloid protein precursor (APP) at ß- and ?-sites by proteases. The longsought ß-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at ß-site and at a different site within Aß8.BACE2 locates on chromosome 21q22.3, the so-called "e;Down critical region"e;, suggesting that BACE2 and Aß may also contribute to the pathogenesis of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
56 kDa aspartic-like protease; AEPLC; ALP56; asp 1; ASP1; ASP21; aspartyl protease 1; BACE2; BAE2; beta secretase 2; beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP cleaving enzyme 2; CDA13; CEAP1; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1
1110059C24Rik; AEPLC; AI850424; ALP56; ARP1; ASP1; ASP21; BACE2; BAE2; CDA13; CEAP1; DRAP; UNQ418/PRO852