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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide APTPGPGTPAERHADG, corresponding to amino acids 44-59 of Human BACE 2.|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-30765 detects BACE2 from rat, human, mouse samples.
PA1-30765 has been successfully used in Western blot applications.
The PA1-30765 immunogen is: Synthetic peptide: APTPGPGTPAERHADG, corresponding to amino acids 44-59 of Human BACE 2.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical regioNULL of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
56 kDa aspartic-like protease; AEPLC; ALP56; asp 1; ASP1; ASP21; aspartyl protease 1; BAE2; beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP cleaving enzyme 2; CDA13; CEAP1; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1
1110059C24Rik; AEPLC; AI850424; ALP56; ARP1; ASP1; ASP21; BACE2; BAE2; CDA13; CEAP1; DRAP; UNQ418/PRO852