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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 336-365 amino acids from the central region of human BACE2|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
56 kDa aspartic-like protease; aspartyl protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Down syndrome region aspartic protease; memapsin 1; memapsin-1; membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1
AEPLC; ALP56; ASP1; ASP21; BACE2; BAE2; CDA13; CEAP1; DRAP; UNQ418/PRO852