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BACE2 Polyclonal Antibody
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FIGURE: 1 / 11
BACE2 Antibody (PA5-145367) in IHC (P)
Immunohistochemistry (Paraffin) analysis of BACE2 in mouse cardiac muscle tissue using BACE2 Polyclonal Antibody (Product # PA5-145367) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-145367
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Rat BACE2 protein, Gly242-Val502 (Accession #Q6IE75)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 56 kDa aspartic-like protease; Asp1; aspartyl protease 1; be; beta secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP processing enzyme; beta-site APP-cleaving enzyme 2; Down syndrome region aspartic protease; memapsin-1; membrane-associated aspartic protease 1; SLCO3A1/BACE2 fusion; theta-secretase; transmembrane aspartic proteinase Asp1; unnamed protein product
Gene Aliases: 1110059C24Rik; AEPLC; ALP56; ARP1; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
UniProt ID: (Human) Q9Y5Z0, (Mouse) Q9JL18, (Rat) Q6IE75
Entrez Gene ID: (Human) 25825, (Mouse) 56175, (Rat) 288227
proteolysis
membrane protein ectodomain proteolysis
protein processing
melanosome organization
glucose homeostasis
negative regulation of amyloid precursor protein biosynthetic process
beta-amyloid metabolic process
signaling receptor ligand precursor processing
astrocyte activation
peptide hormone processing
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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