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Invitrogen

BAD Polyclonal Antibody

1 Reference
View all (47) BAD antibodies

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BAD Polyclonal Antibody

Product Details

PA5-11403

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-

Flow Cytometry (Flow)

1:10-1:50
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 92-127 amino acids from human Bad BH3 Domain
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

800 µg

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2062148

Target Information

The protein encoded by BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BAD; BBC6; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; Bcl2-associated agonist of cell death; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; OTTMUSP00000017561; OTTMUSP00000022400; unnamed protein product

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Gene Aliases: AI325008; BAD; BBC2; BBC6; BCL2L8

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UniProt ID: (Human) Q92934, (Mouse) Q61337

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Entrez Gene ID: (Human) 572, (Mouse) 12015

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Function(s)
protein binding phospholipid binding lipid binding protein kinase binding protein phosphatase binding cysteine-type endopeptidase activator activity cysteine-type endopeptidase activator activity involved in apoptotic process protein phosphatase 2B binding protein kinase B binding protein heterodimerization activity
Process(es)
release of cytochrome c from mitochondria glucose catabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell proliferation extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of mitochondrial membrane potential suppression by virus of host apoptotic process cytokine-mediated signaling pathway positive regulation of insulin secretion positive regulation of glucokinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus glucose homeostasis regulation of apoptotic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process type B pancreatic cell proliferation positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of proteolysis negative regulation of cytolysis ADP metabolic process ATP metabolic process regulation of mitochondrial membrane permeability pore complex assembly positive regulation of epithelial cell proliferation positive regulation of apoptotic process by virus cellular process regulating host cell cycle in response to virus cellular response to organic substance cellular response to nicotine positive regulation of release of cytochrome c from mitochondria apoptotic signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand intrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity positive regulation of neuron death positive regulation of type B pancreatic cell development positive regulation of autophagy negative regulation of apoptotic process epithelial cell proliferation cellular response to mechanical stimulus cellular response to lipid cellular response to hypoxia positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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