Immunogen sequence: QEDSSSAERG LGPSPAGDGP SGSGKHHRQA PGLLWDASHQ QEQPTSSSHH GGAGAVEIRS RHSSYPAGTE DDEGMG
This protein is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death .It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing the death repressor activity. Pro apoptotic activity of protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, and protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of the gene results in two transcript variants which encode the same isoform.
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Protein Aliases: BAD; BBC2; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; BCL2L8
Gene Aliases: BAD; BBC2; BBC6; BCL2L8
UniProt ID: (Human) Q92934
Entrez Gene ID: (Human) 572