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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||synthetic peptide YEEGGKQCVERKCP, corresponding to C terminal amino acids 416-429 of BAF53A.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-31249 detects BAF53A from human samples.
PA1-31249 has been successfully used in Western blot applications.
The PA1-31249 immunogen is: Synthetic peptide: YEEGGKQCVERKCP, corresponding to C terminal amino acids 416-429 of BAF53A.
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
53 kDa BRG1-associated factor A; actin-like 6; actin-like 6A; actin-like protein 6A; actin-related protein 4; actin-related protein Baf53a; ACTL6; Arp4; ARPN-BETA; arpNbeta; BAF complex 53 kDa subunit; BAF53; BAF53A; BRG1-associated factor 53A; BRG1/brm-associated factor 53A; hArpN beta; INO80 complex subunit K; INO80K; MGC5382
2810432C06Rik; ACTL6; ACTL6A; AI851094; ARP4; ARPN-BETA; BAF53; BAF53A; C79802; INO80K; RGD1307747