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Invitrogen
BAFF Polyclonal Antibody
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FIGURE: 1 / 1
BAFF Antibody (PA1-41266) in WB
Western blot analysis of BAFF in mouse and human lysates. Samples were incubated in BAFF polyclonal antibody (Product # PA1-41266) using a dilution of 2 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. Lane A: mouse testis, Lane B: mouse thymus, Lane C: mouse spleen, and Lane D: HL-60 cells (human). PicoTect ECL substrate solution was used for this test.
Product Details
PA1-41266
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C-terminal peptide corresponding to amino acids 254-269 of human TNFSF13B.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: HL-60 whole cell lysate, antigen standard for TNFSF13B (transient overexpression lysate), mouse spleen protein, mouse testis protein, mouse testis, thymus, or spleen, or HL-60, mouse thymus protein.
Target Information
BAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival. Isoforms representing alternatively spliced, and glycosylated variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ApoL related ligand TALL-1; b cell-activating factor; B lymphocyte stimulator; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLyS; CD257; delta BAFF; Delta4 BAFF; Dendritic cell-derived TNF-like molecule; TALL-1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF- and APOL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily member 13b; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand 7A; Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor-like protein ZTNF4
Gene Aliases: BAFF; BLYS; CD257; D8Ertd387e; DTL; TALL-1; TALL1; THANK; TNFSF13B; TNFSF20; TNLG7A; UNQ401/PRO738; ZTNF4
UniProt ID: (Human) Q9Y275, (Mouse) Q9WU72
Entrez Gene ID: (Human) 10673, (Mouse) 24099
B cell homeostasis
positive regulation of germinal center formation
immune response
positive regulation of B cell proliferation
T cell costimulation
B cell costimulation
positive regulation of T cell proliferation
immunoglobulin secretion
regulation of immune response
signal transduction
cell proliferation
positive regulation of cell proliferation
tumor necrosis factor-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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